Research and Grants
In addition to our free wig provision, we fund research into
finding better treatments for childhood cancers.
The Little Princess Trust provides free, real hair wigs to children and young people. But did you know, the charity also funds research for better and kinder treatments into childhood cancers?
Since 2016, we have committed more than £20million across almost 105 projects covering a range of childhood cancers.
And we promise we won’t stop funding new treatments and clinical trials until we reach our goal of ensuring that no child dies from cancer. It is an ambitious target but we believe that with the continued backing from our amazing supporters our aim is achievable.
The Little Princess Trust will also always fulfil its original promise of providing real hair wigs, free of charge, to every child and young person up to the age of 24 who needs one. The focus of the research we fund is closely linked to this pledge and sees us fund studies that not only look for ways to improve a young person’s chance of survival but to do so while reducing the side effects from treatment.
The incredible way we can both provide wigs and fund research is only made possible by the phenomenal work of our fantastic fundraisers. The small team at The Little Princess Trust is continually blown away by the staggering sums of money raised by its supporters as well as the tens of thousands of hair donations received each year.
The Little Princess Trust works in partnership with the Children’s Cancer and Leukaemia Group (CCLG) to find the most suitable projects and administer our research strategy. CCLG offers LPT expertise and advice in selecting and funding the highest quality research, and administer our grant awards. By working together, we ensure every project we fund is of the highest quality and has the potential to improve outcomes for children while also minimising any duplication of resources so more money is spent directly on research.
To read more about the work of our researchers and COVID-19, see https://www.cclg.org.uk/our-research-projects/LPT
Meanwhile, to read The Little Princess Trust Research Strategy, see this link
The Little Princess Trust has been funding research into cancers affecting children and young people since 2016.
We fund research that will lead to kinder, more targeted, less toxic and more effective treatments for all childhood cancers. Read more in our research Strategy below or click here for the pdf.
Read more about our latest projects:
- "Getting it right first time" for children with renal tumours
- Investigating the genetic pathways that control leukaemia growth
- Mapping drug targets in aggressive non-Hodgkin lymphoma
- Using an antibody 'smart bomb' to help the body fight cancer
- Using digital technology to improve our understanding of rhabdomyosarcoma
- Using repurposed drugs to repair the damage that causes AML (Acute Myeloid Leukemia)
- Investigating the potential benefits of proton beam therapy for abdominal tumours
- Repurposing existing drugs to improve outcomes in Ewing sarcoma
- Using next-generation gene technology to help children with blood cancers in Tanzania
More information on our research projects.
How research projects are selected
The Little Princess Trust’s process of awarding new research grants is based on guidance from the Association of Medical Research Charities (AMRC) and carried out in partnership with CCLG.
This provides LPT with a consistent process for all competitive research applications. At the heart of this process is a rigorous system for peer review, ensuring that all new research funded by LPT has been subject to independent scrutiny by those with relevant expertise (peers).
It is the advice of independent experts about the scientific quality of research that informs decisions about which proposals are funded.
The aim of this process is to draw from leading insight from across the paediatric oncology community to help guide the most effective use of LPT’s resources to help maximise the impact of funding.
This process is administered for LPT in line with our research strategy by CCLG. The final decision on awarding grants is made by the Trustees of LPT (delegated to the Research Funding Sub-Committee) taking into account the results of peer review and the recommendations of the CCLG Research Advisory Group.
You can find out more about this process here.
The Little Princess Trust endorses all AMRC regulations, including their position statement supporting research in universities and supporting the use of animals in research.
Animals in research
The research goal at The Little Princess Trust is to develop more effective, kinder treatments for children with cancer.
We provide funding for a range of non-animal research techniques such as cell culture, genetic analysis, medical imaging, and computer modelling.
Despite advances in non-animal methods, which we fully support, there are instances where there is no viable alternative and we will fund animal research.
For example, potential new cancer treatments must still be tested in animals (usually mice) before they can advance to clinical trials in patients (this is from the European Directive 2003/63/EC, Annex 1, Part 1, Module 5).
In instances where we do fund animal research, it is typically one aspect of a larger study and strict guidelines must be followed.
This is never a decision we take lightly, and our application form requires that the researcher has the appropriate licences for animal work which involves regular stringent review by the relevant ethical review body.
Furthermore, the researcher must clearly describe how they have considered the 3Rs in their proposal.
The 3Rs seek to Replace, Refine and Reduce animal use in research.
The Little Princess Trust is committed to the replacement, refinement, and reduction of animal use in research.